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. 2018 Feb 8;11:19. doi: 10.3389/fnmol.2018.00019

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Copyright © 2018 Tröster, Haseleu, Petersen, Drees, Schmidtko, Schwaller, Lewin, Ter-Avetisyan, Winter, Peters, Feil, Feil, Rathjen and Schmidt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pain behavior in cGKI^KO/fl;Wnt1^Cre and littermate control mice. (A) Thermal heat pain was assessed on a 50, 52, and 54°C hot plate (n = 16; ^*p < 0.05; power 99, 47, and 90% for 50, 52, and 54°C, respectively). (B) Cold pain was investigated using acetone-evoked evaporative cooling (n = 16, power 11%). (C) Mechanical sensitivity was measured using a dynamic plantar test (n = 12, power 20%). (D) The nocifensive response to a chemical pain stimulus was determined by injection of 5 μg capsaicin (n = 9, power 61% for licking and 12% for paw shakes) into a hindpaw. ^*p < 0.05.