Skip to main content
. 2018 Feb 8;9:210. doi: 10.3389/fimmu.2018.00210

Figure 5.

Figure 5

Leucine-rich repeat kinase 2 (LRRK2) deficiency in dendritic cells (DCs) leads to increased IL-2 production and nuclear factor of activated T cells (NFAT) translocation in response to Aspergillus fumigatus. (A) IL-2, IL-12/IL-23p40, and IL-23 cytokine production of wild-type (closed circles) and LRRK2−/− (open circles) bone marrow-derived DCs in response to fungal stimulation with A. fumigatus swollen conidia. Data is displayed as the mean cytokine concentration ± SD of two biological replicates and statistical significance determined by one-way ANOVA with Bonferroni’s Multiple Comparison post-test. (B) NFAT translocation measured by luminescence signal in A-sw-stimulated NFAT-luciferase reporter D1 cells upon LRRK2 silencing. Data is displayed as the mean luminescence signal ± SD of three biological replicates and statistical significance determined by Student’s t-test. Differences found to be statistically significant are indicated (*, p < 0.05; **, p < 0.01; ****, p < 0.0001). Abbreviations: Untreated (Unt); A. fumigatus swollen conidia (A-sw).