Figure 4.

A: Time course of ¹H₂O-T₂ changes in posterior hindlimb muscles of B10-mdx, DBA2, and D2-mdx mice. In addition, significant differences are seen among groups at 26 and 28 weeks of age. B: Longitudinal MRI-T₂ of anterior and posterior compartment muscles of D2-mdx mice, demonstrating a significant decrease at 26 weeks of age. C: Axial T₂-weighted MR images of B10-mdx and D2-mdx mice, aged 6 and 28 weeks, showing presence of hyperintense areas in anterior and posterior compartment at 6 weeks of age (red arrows), but these hyperintense areas are absent at 28 weeks of age. In addition, both B10-mdx and D2-mdx demonstrate significant differences in the size of the anterior and posterior hindlimb muscle compartments. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001. Scale bar = 2 mm (C).