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A: H&E and trichrome stains of gastrocnemius muscle of B10-mdx, DBA2, and D2-mdx mice showing decrease in fiber size and increase in fibrotic tissue accumulation. B: D2-mdx mice have significantly reduced fiber cross-sectional areas compared with B10-mdx and DBA2 mice. C: Increased fibrotic tissue accumulation in gastrocnemius muscle of D2-mdx mice compared with B10-mdx. Data are expressed as means ± SD (B and C). ∗∗∗P < 0.001. Scale bar = 100 μm (A). Original magnification, ×20 (A).
