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Notch signaling through the primary cilium. A Notch receptor binds to a membrane-bound Delta or Jagged ligand on an adjacent cell, stimulating proteolytic cleavage of the Notch intracellular domain (NCID) by Presenilin, allowing NCID to translocate to the nucleus where it can activate downstream target genes in association with RBPj DNA binding protein. This is dependent on correct localisation of Presenilin to the basal body, controlled by ARF4 exocytosis.
