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Col5a2 knockdown in vascular SMCs increases the diameters of elastase-induced AAAs. A: Image of representative AAAs, 2 weeks after elastase treatment, of Myh11-Cre; Col5a2fl/fl mice treated with tamoxifen or with vehicle. Arrowheads indicate borders of aortic dilation. B: Quantification of AAA maximal external infrarenal aortic diameters. n = 9 (A, tamoxifen treatment); n = 8 (A, vehicle treatment). ∗P < 0.05.
