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. 2017 Oct;187(10):2300–2311. doi: 10.1016/j.ajpath.2017.06.006

Figure 6.

Figure 6

Col5a2 deficiency also exacerbates Ang II–induced AAA formation in mice. A: AAA incidence. B: Quantification of AAA maximal external suprarenal aortic diameter on day 28. An AAA is defined as percentage increase in aortic diameter of ≥50% (red dashed line). C: AAA classification in Col5a2+/+ versus Col5a2+/− mice after 28 days of Ang II infusion. D: Representative images of aortas. Arrowheads demarcate the area of the abdominal aorta treated with elastase. For comparing AAA incidence, Fisher's exact probability test was used. For comparison of aortic diameter differences, Mann-Whitney U test was used. n = 3 (A, both genotypes of saline controls); n = 9 (A and C, Col5a2+/+ Ang II group); n = 7 (A and C, Col5a2+/− Ang II group). ∗∗P < 0.01.