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. 2017 Oct;187(10):2300–2311. doi: 10.1016/j.ajpath.2017.06.006

Figure 7.

Figure 7

Col5a2 deficiency predisposes mice to aortic dissection and ruptures after Ang II infusion. A: Mortality due to aortic dissection and rupture within the first 7 days of Ang II treatment. Fisher's exact probability test was used to compare Col5a2+/+ versus Col5a2+/−. Of the deaths, 50% were because of Debakey type I dissection, 16% were because of type II dissection, and 33% were because of type III dissection. B: Kaplan-Meier survival curve (P = 0.03, log-rank test). C: Representative image of dissection. D: Hematoxylin and eosin–stained section of thoracic dissection and rupture (arrow). n = 9 (A, Col5a2+/+); n = 13 (A, Col5a2+/−); n = 3 (A, type I dissection); n = 1 (A, type II dissection); n = 2 (A, type III dissection). ∗P < 0.05. Scale bar = 200 μm (D).