Fig. 3.

PCP signaling-regulated cell migration by endocytosis of adhesion plaques. Adhesion plaques serve as anchors to neighboring cells or substrates (1). Noncanonical Wnt signaling activates the internalization of the plaque components cadherin and protocadherin, predominantly in the rear of the cell (2). Cadherins are routed through the endocytic pathway from Rab5 early endosomes to Rab4/11 recycling endosomes (3). This allows for the assembly of new anchor points at the front of the cell. Cadherins are also routed for degradation to Rab7-positive endosomes and Lamp1 lysosomes (4). The differential rate between recycling and degradation determines the amount of Cadherin available for adhesion