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. 2018 Feb 12;8:2833. doi: 10.1038/s41598-018-21324-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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OPN deficiency results in loss of serial reconstitution ability in aged animals. (A) Schematic of the transplantation and analysis setting. Bone marrow from CD45.1-bearing WT or OPN-KO mice was transplanted into lethally irradiated CD45.2-bearing recipients and monitored for peripheral blood and bone marrow reconstitution. (B) Short- and (C) long-term analysis of peripheral blood cells at 5 and 16 weeks after transplantation. (D) Total leukocyte count and leukocyte subsets from a secondary bone marrow transplant. (E) Red blood cell and platelet counts in the secondary recipients of aged OPN−/− and WT bone marrow 10 weeks after bone marrow transplant. (F) Analysis of blood cell counts of the same mice 16 weeks after the second round of bone marrow transplant. (G) Kaplan Meier plot indicating survival after third round of bone marrow transplant. Values are the mean ± SD, n ≥ 7, *P < 0.05, **P < 0.01, ***P < 0.001.