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. 2018 Feb 12;8:3052. doi: 10.1038/s41598-017-13139-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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C23 improves lung histological architecture after CLP. At 20 h after CLP, (A) the lungs of sham-operated mice showed normal histological architecture, while the lungs of septic mice treated with (B) vehicle or (C) C23 displayed alveolar wall thickening with predominantly interstitial neutrophil accumulation. HE staining; representative photomicrographs, 200×. (D) The lung histological injury score, graded by an investigator blinded to the interventions, was significantly higher in mice adjuvantly treated with vehicle than in mice treated with C23. Data are presented as means ± SE. Number of animals in each group: sham n = 5, vehicle n = 12, C23 n = 11. *p < 0.05 vs. sham, ^#p < 0.05 vs. vehicle; one-way ANOVA followed by Student-Newman-Keuls test.