Figure 8.

Schematic diagram depicting the induction of mother vessels (MV) and stabilized MV from normal capillaries and venules by adenovirus expressing vascular endothelial growth factor (VEGF)-A (Ad-VEGF-A¹⁶⁴). MV, but not stabilized MV, revert within hours to normal microvessels by way of glomeruloid microvascular proliferations (GMP) after VEGF inhibition by anti-VEGF/VEGF receptor (VEGFR) drugs or as VEGF levels decline over days to weeks in the absence of treatment as adenovirus is discharged stochastically from infected cells.