Figure 1.

Protein sequence diversity of IFN-γ within rodent species. (a) Amino acid sequence similarity (in percentage) of IFN-γ proteins. On the left, a taxonomic species tree is shown, whereby Peromyscus maniculatus and H. sapiens served as more distant species for comparison. The Arvicolinae (red branches) and the Murinae species (blue branches) are indicated. (b) IFN-γ amino acid sequence comparison between different rodent species and H. sapiens. Light blue indicates lower percentage of identity than dark blue. Arrow head indicates the M. musculus signal peptide cleavage site. Residues involved in the binding to the receptor subunit IFN-γR1 are highlighted by red boxes. Functionally important regions and the C-terminal basic domain are indicated²⁹.