Figure 9.

Proposed effect of PDGFRα blockade on HSC migration and proliferation through inhibition of specific downstream signaling. A: In response to PDGFRα activation by autocrine and/or exogenous PDGF, HSC proliferation and migration are induced through activation of FAK, Erk1/2, Elk-1, p38, Akt, mTOR, and CrkII/CrkL signaling. B: Blockade of PDGFRα by olaratumab decreases the above-mentioned signaling mediators, with FAK, Erk1/2, Elk-1, mTOR, and Akt affecting proliferation and Erk1/2, Elk-1, p38, CrkII/CrkL, decreased mTORC1, and increased mTORC2 regulating migration. Decreases in downstream signaling are represented by dashed arrows.