FIG 4.

Effects of serial passage of the viral clones on the cbDI genome content and IFN-β inducibility. (A) Ratios of IFN-β to beta-actin mRNA in cells infected with the indicated viruses. The ratio in the uninfected sample was set to 1. (B and C) The indicated clones were passaged through Vero-TMPRSS2 cells at an MOI of 10 (B) and a volume of 200 μl (C) five times. The cbDI/fullGNM ratio of each sample is shown as in Fig. 1A. The ratio in the wZ stock was set to 1. (D) Ratios of IFN-β to beta-actin mRNAs shown as in Fig. 1A. The ratio in the uninfected sample was set to 1.