FIG 11.
Model for Env trafficking and retention in ERC by truncated FIP1C. (A) Model of Env trafficking through the ERC. In this scheme, step 1 represents trafficking through the secretory pathway to the PM. Step 2 represents clathrin- and AP-2-dependent endocytosis to the ERC. Step 3 is dependent upon FIP1C and Rab14, in which Gag and Env come together at the PM assembly site. (B) Altered Env trafficking by FIP1C560–649. In this model, steps 1 and 2 remain intact but Env is retained on ERC membranes, while step 3 is absent, resulting in particles lacking Env.