TABLE 1.
Associations of HLA alleles with clinical outcomes (n = 536)
| Allele | Population frequency (%) | Median viral load (log10 copies/ml) |
P valuea | Median CD4 count (cells/μl) |
P valuea | ||
|---|---|---|---|---|---|---|---|
| HLA+ | HLA− | HLA+ | HLA− | ||||
| HLA-A alleles | |||||||
| HLA-A*01:01 | 5.8 | 4.67 | 4.56 | 0.37 | 279 | 300 | 0.42 |
| HLA-A*02:01 | 4.1 | 4.5 | 4.56 | 0.68 | 290 | 300 | 0.88 |
| HLA-A*02:03 | 16.2 | 4.67 | 4.55 | 0.14 | 264 | 303 | 0.045 |
| HLA-A*02:06 | 8.8 | 4.46 | 4.57 | 0.31 | 293 | 300 | 0.90 |
| HLA-A*02:07 | 17.5 | 4.58 | 4.56 | 0.54 | 302 | 299 | 0.62 |
| HLA-A*03:01 | 2.4 | 4.16 | 4.57 | 0.083 | 355 | 299 | 0.32 |
| HLA-A*11:01 | 44.4 | 4.52 | 4.58 | 0.16 | 319 | 293 | 0.018 |
| HLA-A*11:02 | 5.8 | 4.58 | 4.56 | 0.89 | 280 | 300 | 0.59 |
| HLA-A*24:02 | 18.1 | 4.54 | 4.57 | 0.73 | 295 | 300 | 0.82 |
| HLA-A*24:07 | 6.7 | 4.71 | 4.56 | 0.29 | 271 | 301 | 0.36 |
| HLA-A*26:01 | 4.5 | 4.8 | 4.56 | 0.14 | 284 | 300 | 0.64 |
| HLA-A*29:01 | 13.8 | 4.82 | 4.54 | 0.012 | 248 | 304 | 0.23 |
| HLA-A*30:01 | 2.4 | 4.39 | 4.57 | 0.32 | 373 | 299 | 0.092 |
| HLA-A*31:01 | 3.2 | 4.29 | 4.57 | 0.18 | 359 | 299 | 0.23 |
| HLA-A*33:03 | 25.2 | 4.55 | 4.57 | 0.69 | 306 | 299 | 0.54 |
| HLA-B alleles | |||||||
| HLA-B*07:02 | 2.6 | 4.74 | 4.56 | 0.47 | 338 | 299 | 0.40 |
| HLA-B*07:05 | 15.3 | 4.77 | 4.54 | 0.019 | 242 | 305 | 0.009 |
| HLA-B*13:01 | 9.3 | 4.58 | 4.56 | 0.86 | 293 | 300 | 0.81 |
| HLA-B*15:01 | 2.2 | 4.57 | 4.56 | 0.93 | 388 | 298 | 0.12 |
| HLA-B*15:02 | 26.9 | 4.63 | 4.55 | 0.33 | 291 | 301 | 0.75 |
| HLA-B*15:12 | 3.9 | 4.86 | 4.56 | 0.073 | 278 | 300 | 0.51 |
| HLA-B*15:25 | 10.3 | 4.42 | 4.57 | 0.20 | 284 | 300 | 0.50 |
| HLA-B*27:04 | 2.1 | 4.35 | 4.57 | 0.33 | 248 | 300 | 0.56 |
| HLA-B*35:05 | 5.2 | 4.58 | 4.56 | 0.87 | 271 | 300 | 0.31 |
| HLA-B*37:01 | 2.2 | 4.71 | 4.56 | 0.51 | 323 | 299 | 0.60 |
| HLA-B*38:02 | 12.7 | 4.63 | 4.56 | 0.47 | 288 | 300 | 0.73 |
| HLA-B*40:01 | 9.1 | 4.42 | 4.57 | 0.25 | 317 | 299 | 0.62 |
| HLA-B*40:06 | 2.6 | 4.53 | 4.56 | 0.89 | 345 | 299 | 0.38 |
| HLA-B*44:03 | 5.8 | 4.36 | 4.57 | 0.16 | 314 | 299 | 0.80 |
| HLA-B*46:01 | 20.5 | 4.46 | 4.58 | 0.21 | 316 | 298 | 0.52 |
| HLA-B*51:01 | 4.7 | 4.51 | 4.56 | 0.60 | 292 | 300 | 0.78 |
| HLA-B*51:02 | 2.6 | 4.74 | 4.56 | 0.49 | 262 | 300 | 0.74 |
| HLA-B*52:01 | 3.7 | 4.35 | 4.57 | 0.22 | 377 | 298 | 0.059 |
| HLA-B*54:01 | 4.3 | 4.62 | 4.56 | 0.71 | 364 | 298 | 0.13 |
| HLA-B*55:02 | 6.2 | 4.73 | 4.56 | 0.21 | 298 | 300 | 0.90 |
| HLA-B*57:01 | 4.7 | 4.51 | 4.56 | 0.74 | 291 | 300 | 0.95 |
| HLA-B*58:01 | 17.0 | 4.51 | 4.57 | 0.52 | 343 | 296 | 0.087 |
| HLA-C alleles | |||||||
| HLA-C*01:02 | 27.4 | 4.54 | 4.57 | 0.85 | 316 | 297 | 0.56 |
| HLA-C*03:02 | 17.4 | 4.53 | 4.57 | 0.94 | 341 | 296 | 0.13 |
| HLA-C*03:03 | 8.6 | 4.85 | 4.55 | 0.017 | 271 | 301 | 0.38 |
| HLA-C*03:04 | 11.8 | 4.58 | 4.56 | 0.98 | 274 | 301 | 0.44 |
| HLA-C*04:01 | 6.5 | 4.49 | 4.57 | 0.56 | 290 | 300 | 0.75 |
| HLA-C*04:03 | 8.8 | 4.52 | 4.56 | 0.65 | 283 | 300 | 0.70 |
| HLA-C*06:02 | 7.3 | 4.54 | 4.56 | 0.99 | 304 | 299 | 0.96 |
| HLA-C*07:01 | 6.2 | 4.37 | 4.57 | 0.16 | 308 | 299 | 0.89 |
| HLA-C*07:02 | 30.2 | 4.52 | 4.57 | 0.33 | 312 | 297 | 0.27 |
| HLA-C*08:01 | 30.6 | 4.61 | 4.55 | 0.58 | 284 | 303 | 0.59 |
| HLA-C*12:02 | 5.6 | 4.22 | 4.57 | 0.016 | 370 | 297 | 0.040 |
| HLA-C*12:03 | 3.7 | 4.53 | 4.56 | 0.94 | 315 | 299 | 0.99 |
| HLA-C*14:02 | 4.3 | 4.52 | 4.56 | 0.93 | 258 | 300 | 0.21 |
| HLA-C*15:02 | 4.3 | 4.66 | 4.56 | 0.43 | 299 | 300 | 0.77 |
| HLA-C*15:05 | 13.6 | 4.8 | 4.54 | 0.022 | 238 | 304 | 0.014 |
a
Analyzed by use of a linear regression model.