TABLE 3.

HLA-A*29:01-, -B*07:05-, and -C*15:05-associated HIV-1 mutations in HIV-1 subtype A/E-infected Vietnamese individuals

Gene product	Position	Amino acid mutation	Consensus amino acida	Direction of adaptionb	P valuec
					HLA-A*29:01	HLA-B*07:05	HLA-C*15:05
Pol	14	R	K	Adapted	0.03	0.002	0.002
	110	K	T	Adapted	0.0002	<0.0001	<0.0001
	261	Y	C	Adapted	0.003	0.0004	0.0006
	272	I	I	Nonadapted	0.04	0.0006	0.0003
	653	L	S	Adapted	0.0008	0.002	0.0008
	653	A	S	Adapted	0.0002	<0.0001	<0.0001
	653	T	S	Adapted	0.0002	<0.0001	<0.0001
	655	V	I	Adapted	<0.0001	<0.0001	<0.0001
	657	R	K	Adapted	0.0002	0.0004	<0.0001
Nef	71	K	R	Adapted	0.2	<0.0001	0.04
	156	N	D	Nonadapted	0.04	0.003	0.01
	173	I	F	Adapted	0.004	0.01	0.001

^aCohort consensus sequence.

^bAdapted, amino acids are abundant in the “presence” of a given HLA allele; nonadapted, amino acids are abundant in the “absence” of a given HLA allele.

^cAnalyzed by Fisher's exact test.