Table 3.
Results of sympathetic activity and systemic parameters during modest ICP increase and decrease in human (n = 10).
| ICP | Baseline | 10 mmHg | 15 mmHg | 20 mmHg | Plateau | Post infusion |
|---|---|---|---|---|---|---|
| CSF Pressure (mmHg) | 8.28 ± 1.05 | 10.72 ± 0.40 | 15.64 ± 0.22 | 20.43 ± 0.31** | 25.05 ± 0.33** | 14.83 ± 0.91† |
| MSNA (bursts.min−1) | 51.24 ± 2.52 | 53.85 ± 2.54 | 59.95 ± 2.96** | 66.50 ± 4.17** | 66.70 ± 2.88** | 58.85 ± 2.62*† |
| MSNA (bursts /100 HB) | 82.86 ± 3.16 | 88.04 ± 5.54 | 98.60 ± 5.47** | 107.50 ± 5.54** | 106.00 ± 6.57** | 96.23 ± 4.41**† |
| ABPs (mmHg) | 145.89 ± 9.56 | 148.04 ± 9.96 | 149.64 ± 9.42 | 150.43 ± 9.97 | 153.28 ± 10.04 | 152.67 ± 10.67 |
| ABPd (mmHg) | 74.57 ± 3.83 | 75.36 ± 3.84 | 74.41 ± 3.84 | 74.41 ± 3.78 | 77.10 ± 3.18 | 77.79 ± 4.08 |
| HR (beats.min−1) | 62.39 ± 3.54 | 62.44 ± 3.75 | 61.63 ± 3.30 | 62.37 ± 3.52 | 63.04 ± 3.66 | 63.44 ± 3.17 |
| Oxygen saturation (%) | 94.98 ± 1.03 | 94.96 ± 0.92 | 94.99 ± 0.96 | 94.96 ± 0.87 | 95.45 ± 0.87 | 95.85 ± 0.91 |
| Respiratory rate (min−1) | 17.06 ± 1.02 | 17.10 ± 1.06 | 17.26 ± 1.13 | 17.18 ± 1.07 | 17.01 ± 1.11 | 17.36 ± 1.07 |
| Respiratory amplitude (%) | 100.0 ± 0.0 | 103.7 ± 1.4 | 118.2 ± 11.0 | 129.6 ± 12.4 | 133.6 ± 14.0* | 123.0 ± 12.7 |
Cerebrospinal fluid (CSF) pressure, muscle sympathetic nerve activity (MSNA) expressed in bursts.min-1 and bursts/100 HB, systolic arterial blood pressure (ABPs), diastolic arterial blood pressure (ABPd), heart rate (HR), oxygen saturation, respiratory rate and respiratory amplitude were calculated in patients during 60 s epochs at different ICP levels: 8 mmHg (baseline), 10 mmHg, 15 mmHg, 20 mmHg, 25 mmHg (plateau), and 15 mmHg (post-infusion, i.e., 5 min after the end of the infusion). Values are depicted as mean ± sem. Statistical analysis was carried out using ANOVA.
p < 0.05,
p < 0.01 vs. baseline and
p < 0.05,
p < 0.01 vs. plateau.