Interactions of patch-type, time, and ovarian hormones. Note. (a and b) Estimated marginal means±standard error over time for interaction effects between patch-type × time. (c) Estimated marginal means±standard error at low (1 SD below mean) and high (1 SD above mean) progesterone over time. (d) Estimated marginal means±standard error at low (1 SD below mean) and high (1 SD above mean) estradiol. CFB, change from baseline; QSU, questionnaire of smoking urges; NA, negative affect; Pro, progesterone; TNP, transdermal nicotine patch; PBO, transdermal placebo patch.