Table 2. Effects of Progesterone on Smoking-Related Outcomes.

	MNWS			QSU			NA			Length delayed		Cigs smoked
	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3	Model 1	Model 2	Model 1	Model 2
Fixed effects
Intercept	−0.51	−0.51	−0.51	−0.47	−0.47	−0.50	−0.11	−0.11	−0.11	25.10	25.10	0.79	0.79
Patch	0.08	0.08	0.09	0.06	0.06	0.10	0.00	0.01	0.01	14.88**	14.88**	−0.47	−0.47
Time	0.03	0.03	0.03	−0.02	−0.03	−0.02	0.00	0.00	0.00
Patch × Time	−0.04	−0.04	−0.04	−0.09***	−0.09***	−0.09***	0.00	0.00	0.00
Progesterone—WS	−0.67	−0.70	−0.81	−0.92	−1.92	−2.99***	−0.63***	−0.02	−0.16	−7.11	−6.83	0.82	1.20
Progesterone—WS × Patch		−0.34	−0.02		0.81	3.97**		−0.67	−0.27		−0.65		−0.88
Progesterone—WS × Time		0.07	0.12		0.27	0.72**		−0.14	−0.08
Progesterone—WS × Patch × Time			−0.14			−1.35***			−0.17

Abbreviation: WS, within-subject.

Note: Model 1 tests the association between within-subject progesterone and outcomes controlling for patch, time, patch × time, and relevant covariates. Model 2 tests interactive effects of within-subject progesterone and patch on smoking and withdrawal-related outcomes and within-subject progesterone and time interactions on withdrawal-related outcomes. Model 3 tests the three-way interaction of within-subject progesterone, patch, and time on withdrawal-related outcomes. Models 1–3 included the following covariates: Black (coded 0=Black, 1=Other), years regular smoker, cigarettes per day, number past quit attempts, FTND, session phase, and between-subject progesterone levels. Patch coded 0=0 mg nicotine, 1=21 mg nicotine. ^**p<0.003, ^***p<0.001.