Table 3. Effects of Estradiol on Smoking-Related Outcomes.

	MNWS			QSU			NA			Length delayed		Cigs smoked
	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3	Model 1	Model 2	Model 1	Model 2
Fixed effects
Intercept	−0.51	−0.52	−0.53	−0.52	−0.51	−0.52	−0.13	−0.14	−0.15	26.25**	26.25**	0.77	0.77
Patch	0.03	0.04	0.04	0.07	0.07	0.07	−0.01	−0.01	−0.01	16.03***	16.16***	−0.49	−0.49
Time	0.03	0.03	0.03	−0.02	−0.02	−0.03	0.00	0.00	0.00
Patch × Time	−0.04	−0.04	−0.04	−0.10***	−0.09***	−0.09***	0.00	0.00	0.00
Estradiol—WS	−0.01	0.05	0.00	0.00	−0.05	−0.10	−0.05**	0.05	0.03	0.44	−0.62	0.03	0.10
Estradiol—WS × Patch		−0.15	−0.04		0.12	0.23		−0.12***	−0.09		2.08		−0.15
Estradiol—WS × Time		0.00	0.02		−0.01	0.01		−0.01	−0.01
Estradiol—WS × Patch × Time			−0.04			−0.04			−0.01

Abbreviation: WS, within-subject.

Note: Model 1 tests the association between within-subject estradiol and outcomes controlling for patch, time, patch × time, and relevant covariates. Model 2 tests interactive effects of within-subject estradiol and patch on smoking and withdrawal-related outcomes and within-subject estradiol and time interactions on withdrawal-related outcomes. Model 3 tests the three-way interaction of within-subject estradiol, patch, and time on withdrawal-related outcomes. Models 1–3 included the following covariates: Black (coded 0=Black, 1=Other), years regular smoker, cigarettes per day, number past quit attempts, FTND, session phase, and between-subject estradiol levels. Patch coded 0=0 mg nicotine, 1=21 mg nicotine. ^**p<0.003, ^***p<0.001.