Table 4. Effects of Progesterone to Estradiol (P/E) Ratios on Smoking-Related Outcomes.

	MNWS			QSU			NA			Length delayed		Cigs smoked
	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3	Model 1	Model 2	Model 1	Model 2
Fixed effects
Intercept	−0.54	−0.54	−0.54	−0.45	−0.46	−0.47	−0.14	−0.13	−0.13	26.09	26.07	0.77	0.77
Patch	0.05	0.05	0.05	0.08	0.07	0.12	0.01	0.00	0.00	13.76**	13.82**	−0.43	−0.43
Time	0.03	0.03	0.03	−0.02	−0.02	−0.02	0.00	0.00	0.00
Patch × Time	−0.04	−0.04	−0.04	−0.10***	−0.09***	−0.10***	0.00	0.00	0.00
P/E ratios—WS	−1.98	−2.20	−2.67	−3.18**	−4.91	−8.76***	−0.80	−0.83	−0.83	−12.22	4.14	1.83	3.03
P/E ratios—WS × Patch		0.51	1.52		1.27	9.03**		1.26	1.27		−29.90		−2.11
P/E ratios—WS × Time		−0.02	0.18		0.44	2.05***		−0.28	−0.27
P/E ratios—WS × Patch × Time			−0.44			−3.38***			0.00

Abbreviation: WS, within-subject.

Note: Model 1 tests the association between within-subject P/E ratios and outcomes controlling for patch, time, patch × time, and relevant covariates. Model 2 tests interactive effects of within-subject P/E ratios and patch on smoking and withdrawal-related outcomes and within-subject P/E ratios and time interactions on withdrawal-related outcomes. Model 3 tests the three-way interaction of within-subject P/E ratios, patch, and time on withdrawal-related outcomes. Models 1–3 included the following covariates: Black (coded 0=Black, 1=Other), years regular smoker, cigarettes per day, number past quit attempts, FTND, session phase, and between-subject P/E ratios. Patch coded 0=0 mg nicotine, 1=21 mg nicotine. ^**p<0.003, ^***p<0.001.