Table 4.
Changes in NSE levels after 3 days of treatment in children with HIE
| ∆NSE | |||||||
|---|---|---|---|---|---|---|---|
| Group | Time window | Mild | Moderate | Severe | |||
| N | Mean ± SD | N | Mean ± SD | N | Mean ± SD | ||
| Control group | < 6 h | 14 | 4.0 ± 0.6 | 14 | 19.1 ± 2.4b1 | 13 | 12.1 ± 0.3c1 |
| ≥ 6 h | 13 | 5.2 ± 1.5 | 9 | 21.4 ± 3.6b2 | 9 | 16.8 ± 5.2c2 | |
| Hypothermia group | < 6 h | 15 | 2.0 ± 0.8 | 10 | 13.7 ± 1.8b1 | 6 | 14.3 ± 3.9c1 |
| ≥ 6 h | 9 | 3.9 ± 2.8 | 7 | 15.3 ± 5.1b2 | 5 | 19.8 ± 1.9c2 | |
| P | 0.35a | < 0.01b | < 0.05c | ||||
∆ Before and after treatment; ano statistically significant difference between mild HIE groups (P > 0.05), bmoderate HIE groups showed statistically significant differences (P < 0.01): b1moderate HIE and < 6 h subgroup (P < 0.05), b2 moderate HIE and 6-12 h subgroup (P < 0.05); csevere HIE patients showed statistically significant differences between the subgroups (P < 0.05): c1severe HIE and < 6 h subgroup (P < 0.05) c2severe HIE and 6-12 h subgroup (P > 0.05); two initiation time windows in the hypothermia group showed no difference in moderate HIE patients (b1b2 HIE; P > 0.05) but in severe HIE patients (c1c2 P < 0.05)