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. 2018 Feb 12;19:51. doi: 10.1186/s12859-018-2042-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Sequence-based Map of H1N1 HA Proteins. Antigenic cartography of sequence-based antigenic distance calculations for HA protein sequences on 4838 H1N1 viruses. Each point on the map represents a HA protein antigen. The distance between two HA protein antigens on the map represents the antigenic distance between the two antigens. Historical Strains are labeled. Points are colored based on categorical hierarchical clustering