Table 1.
Pharmacokinetic parameters of MH84
| Parameter | Value |
|---|---|
| Cmax (μg/g plasma) | 10.90 |
| Tmax (h) | 3.00 |
| AUC48h (μg h/ml) | 89.58 |
| T1/2 (h) | 3.24 |
| CL (ml/min/kg) | 2.23 |
| Vd (L/kg) | 0.63 |
Plasma levels of MH84 were determined using HPCL after single oral gavage of 12 mg/kg MH84. The following pharmacokinetic parameters were adopted from our previous publication (for details, please refer to Pellowska et al. [35]): Cmax, maximum concentration; Tmax, time to reach Cmax; AUC48h, area under the curve until 48 h; T1/2, half-life time; CL, clearance; Vd, volume of distribution
MH84 ethyl 2-(4,6-bis(4-(trifluoromethyl)phenethoxy)pyrimidin-2-yl-thio)hexanoate