. 2018 Feb 8;8:32. doi: 10.3389/fcimb.2018.00032

Table 3.

CRP-S (CRE) promoter sites identified in 11 competence genes in H. parasuis SC1401.

	Name	P-value		CRP-S Sites
1.	radC (A4U84_RS03695)	3.04e-12	AACGCCCTAT	$TTTTT$ $G$ $C$ $G$ $A$ $T$ $C$ $TTT$ $G$ $T$ $C$ $G$ $AAAAA$	AGAGAAAAAG
2.	A4U84_RS08565	1.35e-12	AAAAAATAAA	$TTTTT$ $C$ $G$ $A$ $T$ $C$ $T$ $C$ $T$ $G$ $T$ $C$ $G$ $AAAAA$	TTAAAAGAAT
3.	pilA (A4U84_RS08530)	5.39e-12	AAAAAACGAT	$TTTTT$ $C$ $G$ $A$ $T$ $C$ $T$ $A$ $C$ $G$ $T$ $C$ $G$ $AAAAA$	ATAAATGTTG
4.	comE1 (A4U84_RS07375)	1.85e-12	ATTTTTCAAT	$TTTTT$ $C$ $G$ $A$ $T$ $C$ $T$ $G$ $C$ $G$ $T$ $C$ $G$ $AAAAA$	CACATTTTTA
5.	A4U84_RS02730	5.39e-12	GCCGAACTAT	$TTTT$ $G$ $T$ $G$ $A$ $T$ $CCCC$ $G$ $T$ $C$ $G$ $AAAAA$	TTCATTATTT
6.	comN (A4U84_RS02240)	1.08e-11	ATCTTTCTAA	$TTTTT$ $C$ $G$ $A$ $T$ $C$ $T$ $A$ $T$ $G$ $T$ $C$ $G$ $AAAAA$	ATAAAAATTG
7.	rec-2 (A4U84_RS10535)	1.08e-11	CAATATTTAT	$TTTT$ $G$ $T$ $G$ $A$ $T$ $CCC$ $T$ $G$ $T$ $C$ $G$ $AAAAA$	CATTATTTTT
8.	comA (A4U84_RS02030)	1.77e-10	TAAATATGAT	$TTTT$ $A$ $C$ $G$ $A$ $T$ $C$ $TT$ $C$ $A$ $T$ $C$ $G$ $AAAAA$	TTCTCTTTTG
9.	comF (A4U84_RS05740)	1.62e-10	ATTTTACTCT	$TTTTT$ $C$ $G$ $A$ $T$ $CC$ $G$ $T$ $G$ $T$ $C$ $A$ $C$ $AAAA$	ATTCCCCAAA
10.	comM (A4U84_RS06900)	7.69e-10	CTTTAACTAT	$TTTT$ $G$ $T$ $G$ $A$ $C$ $A$ $C$ $T$ $C$ $G$ $T$ $C$ $G$ $AAAAA$	CCAACATTTT
11.	ssb (A4U84_RS00055)	7.55e-9	AAATTTTCAA	$A$ $TTTT$ $C$ $G$ $A$ $T$ $C$ $A$ $TT$ $A$ $T$ $C$ $G$ $C$ $A$ $T$ $A$ $A$	ATTGATTAAC
12.	dprA (A4U84_RS04945)	4.46e-8	AACGATGAAA	$A$ $TTTT$ $C$ $T$ $A$ $CC$ $T$ $CC$ $AA$ $C$ $AAA$ $G$ $AA$	AAAGTTAAAG

CRP-S motif was found in 300 bp upstream of all 12 genes in H. parasuis SC1401. P-value represents the probability that an equal or better site could be found in a random sequence of the same length conforming to the background letter frequencies. Bold and color values indicate flanking regions and their corresponding candidate CRP-S site in the promoter region of different competence gene. Note, the CRP-S motif of dprA is more variable (p-value of 4.46e-8), thus was identified manually.