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. 2018 Feb 12;18:174. doi: 10.1186/s12885-018-4021-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Gene view of AKAP mutations and AKAP protein regions and domains. Drop symbols indicating location of amino acid exchange light green: mutation present only in metastasis; dark green: mutation present in both primary tumor and corresponding metastasis; blue: SNP reported association with familiar breast cancer [46, 48, 66]. PKA-RI/II: protein kinase A regulatory subunit I/II; WSK: short conserved WXSXK motif in protein kinase A binding proteins (AKAPs); ZF: Zinc finger repeats; MCM2: minichromosome maintenance complex 2 [33]; DH: Dbl homology domain (RhoGEF); PH: Pleckstrin homology domain; Protein kinase interacting domains are provided from uniprotKB with additional domains from [32]**. EGFR interacting domain from [63]