Table 2.
Most frequently mutated genes in cohort1 sorted by occurrence in metastases
| Metastasis n = 10 (%) | Primary tumors n = 10 (%) | Primary tumors TCGA (%) | |
|---|---|---|---|
| KMT2C | 6 (60) | 1 (10) | 8 |
| AFF2 | 3 (30) | 3 (30) | 2 |
| KMT2A | 3 (30) | 1 (10) | 2 |
| MED12 | 3 (30) | 1 (10) | 2 |
| ASXL1 | 3 (30) | 1 (10) | 1 |
| FBXO11 | 3 (30) | 0 | 1 |
| TP53 | 2 (20) | 1 (10) | 35 |
| ARID1A | 2 (20) | 1 (10) | 4 |
| NF1 | 2 (20) | 1 (10) | 3 |
| AKAP13 | 2 (20) | 0 | 2 |
| APC | 2 (20) | 1 (10) | 2 |
| ARID1B | 2 (20) | 1 (10) | 2 |
| ATRX | 2 (20) | 1 (10) | 2 |
| CDK12 | 2 (20) | 0 | 2 |
| KDM6A | 2 (20) | 0 | 2 |
| CDH1 | 1 (10) | 0 | 7 |
| PIK3CA | 0 | 1 (10) | 36 |
| AKAP12 | 2 (20) | 0 | 1 |
| ALK | 2 (20) | 1 (10) | 1 |
| ARID2 | 2 (20) | 1 (10) | 1 |
| BAP1 | 2 (20) | 0 | 1 |
| CAMTA1 | 2 (20) | 1 (10) | 1 |
| CLTC | 2 (20) | 0 | 1 |
| DICER1 | 2 (20) | 0 | 1 |
| EML4 | 2 (20) | 0 | 1 |
| EPS15 | 2 (20) | 0 | 1 |
| GNAS | 2 (20) | 0 | 1 |
| KDM5A | 2 (20) | 1 (10) | 1 |
| KDR | 2 (20) | 0 | 1 |
| MET | 2 (20) | 0 | 1 |
| MYH11 | 2 (20) | 0 | 1 |
| NIN | 2 (20) | 0 | 1 |
| NUMA1 | 2 (20) | 0 | 1 |
| NUP98 | 2 (20) | 0 | 1 |
| PCSK7 | 2 (20) | 3 (30) | 1 |
| PDGFRB | 2 (20) | 1 (10) | 1 |
Number of mutated samples n = 10, (%). The third column lists the reported mutation frequencies in TCGA breast cancer [1]
MET metastasis, PT primary tumor, TCGA the cancer genome atlas