Figure 5.
Effect of serotonin on retrogradely labeled L5 pyramidal neurons. Thalamus. A1, IsAHP and Ih recorded from a L5 neuron retrogradely labeled from the thalamus. Ih scale: 200 pA, 1 s. IsAHP scale: 50 pA, 250 ms. The scale applies to panels A1–D1. A2, Summary plot illustrating the mean current (± SEM) elicited by serotonin (10 μm) in neurons retrogradely labeled from the thalamus (n = 5 cells). A3, Graph illustrating the peak serotonin current recorded in these cells. Dorsal raphe. B1, IsAHP and Ih recorded from a L5 neuron retrogradely labeled from the dorsal raphe. B2, Summary plot illustrating the mean current (± SEM) elicited by serotonin (10 μm) in neurons retrogradely labeled from the dorsal raphe (n = 9 cells). B3, Graph illustrating the peak serotonin current recorded in these cells. Striatum. C1, IsAHP and Ih recorded from a L5 neuron retrogradely labeled from the striatum. C2, Summary plot illustrating the mean current (± SEM) elicited by serotonin (10 μm) in neurons retrogradely labeled from the striatum (n = 8 cells). C3, Graph illustrating the peak serotonin current recorded in these cells. Contralateral PFC. D1, IsAHP and Ih recorded from a L5 neuron retrogradely labeled from the contralateral PFC. D2, Summary plot illustrating the mean current (± SEM) elicited by serotonin (10 μm) in neurons retrogradely labeled from the contralateral PFC (n = 11 cells). D3, Graph illustrating the peak serotonin current recorded in these cells. The cells illustrated in panels A–D were assigned a probability of at least 95% for belonging to the type I class (A and B) or the type II class (C and D) by the Bayesian classifier.