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. 2018 Feb 6;5(1):ENEURO.0327-17.2018. doi: 10.1523/ENEURO.0327-17.2018

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Copyright © 2018 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Activation of SiHsTRPA and AmHsTRPA by saturated medium-chain fatty acids. Activation of SiHsTRPA and AmHsTRPA by saturated fatty acids was analyzed by calcium imaging. The mean value of fold change of Fura-2 ratio with error bar (± SEM) is shown for the fatty acid (propionic acid, C3; butyric acid, C4; valeric acid, C5; heptanoic acid, C6; hexanoic acid, C7; octanoic acid, C8; nonanoic acid, C9; decanoic acid, C10; undecanoic acid, C11; and lauric acid, C12) stimulated DsRed-positive (blue) and DsRed-negative (yellow) cells. The total numbers of SiHsTRPA- and AmHsTRPA-transfected cells analyzed were 97–212 and 61–157, respectively. **, Significant difference by one-tailed Welch’s t test (P < 0.001). The traces in extended data Figs. 4-1 and 4-2 indicate the changes of intracellular calcium level in SiHsTRPA- and AmHsTRPA-expressing cells by above fatty acids, respectively.