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. Author manuscript; available in PMC: 2018 Mar 8.
Published in final edited form as: J Am Chem Soc. 2017 Feb 27;139(9):3446–3455. doi: 10.1021/jacs.6b11273

Figure 1.

Figure 1

Overview of miR-210 and Targapremir-210 activity. (A) Schematic of miR-210’s regulatory effect on GPD1L and HIF-1α in hypoxia, which contributes to the metastasis of cancer cells. GPD1L, glycerol-3-phosphate dehydrogenase 1-like enzyme; HIF-1α, hypoxia-inducible factor 1-alpha; HIF-1β, hypoxia-inducible factor 1-beta; PHD, prolyl hydroxylase; UB, ubiquitin; VHL, Von Hippel—Lindau tumor suppressor (E3 ubiquitin protein ligase). (B) Schematic of an approach to inhibit miR-210 biogenesis with a designed small molecule, Targapremir-210.