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. 2018 Feb 12;14(2):e8007. doi: 10.15252/msb.20178007

Figure EV2. Antisense transcription has similar associations with chromatin modifications in both yeast and humans.

Figure EV2

  1. The average levels of H3K36me3 and H3K79me3 in HeLa and S. cerevisiae genes. For each trio of panels, the left panel shows average levels around the sTSS, the right panel shows the average levels around the asTSS, and the middle panel shows the average level within thirty equal sized bins within the region bound by the sTSS and asTSS. Genes considered are selected from those that contained an asTSS, as defined in Fig 1. Shown in red are two sets of genes—those with high levels of sense transcription (dark red), and those with low levels (pale red), determined by GRO‐seq in HeLa cells, and PRO‐seq in budding yeast. Shown in blue are those genes with high levels of antisense transcription (dark blue), and those with low levels (pale blue), determined by GRO‐seq in HeLa cells, and PRO‐seq in budding yeast.
  2. Average levels of H3K4me3 and H3K4me1, laid out as in (A).
  3. Average levels of H3K9ac and H3K27ac, laid out as in (A).