Figure 7. Summary.

1. Schematic outlining the influence of antisense transcription or SET3 deletion on levels of histone lysine acetylation (ac), steady‐state transcript levels (3) and on the rates of transcript production (1), processing and export (2) and transcript decay (4). Line width indicates levels (3) or rates (1, 2, 4) with increased rate represented by extra lines.
2. Relationship of the dependent variables to independent variables in our study. High antisense transcription is associated with a highly acetylated chromatin environment, resulting in slower sense transcription kinetics, namely the initiation rate and elongation/export rate. We mimic this behaviour by deleting SET3, increasing acetylation levels and we observe a reduction in initiation and elongation/export rates.