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. 2018 Jan 18;41(4):1855–1866. doi: 10.3892/ijmm.2018.3405

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Overexpression of miR-21 increases DOX resistance of SGC7901 cells. (A) A reverse transcription quantitative-polymerase chain reaction assay was performed to examine miR-21-5p expression levels after transfection of its mimics (or miR-NC). (B) A cell counting kit-8 assay was used to determine the viability of SGC7901 cells after transfection with miR-21 mimics (or miR-NC) following exposure to various doses of DOX for 48 h. (C) Apoptotic rates of SGC7901 cells were analyzed to determine the role of miR-21-5p on the effects of DOX treatment (1 μg/ml) for 48 h. Late apoptotic or necrotic cells and early apoptotic cells are displayed in Q2 and Q3, respectively. ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. miR-NC. miR, microRNA; FITC, fluorescein isothiocyanate; DOX, doxorubicin; NC, negative control; Q, quadrant.