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. 2018 Jan 18;41(4):1855–1866. doi: 10.3892/ijmm.2018.3405

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PTEN and TIMP3 have a key role in the chemoresistance of SGC7901 cells. (A and B) mRNA levels of PTEN and TIMP3 in SGC7901 cells were reduced after transfection with specific siRNA. (C and D) The protein expression of PTEN and TIMP3 in SGC7901 cells was reduced after transfection with specific siRNA. (E) A cell counting kit-8 assay was performed to detect the effect of siRNA-mediated PTEN and TIMP3 knockdown on the viability of SGC7901 cells. ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. miR-NC. PTEN, phosphatase and tensin homologue; TIMP3, tissue inhibitor of matrix metalloprotein-ases 3; siRNA, small interfering RNA; miR, microRNA; NC, negative control; DOX, doxorubicin.