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. 2018 Jan 18;41(4):1855–1866. doi: 10.3892/ijmm.2018.3405

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PTEN and TIMP3 are downregulated in GC tumor tissues, which negatively correlates with miR-21-5p levels. (A and B) A reverse transcription quantitative-polymerase chain reaction assay was used to measure the expression levels of PTEN and TIMP3 in GC samples and matched adjacent normal tissues. (C) A statistically significant negative correlation between the expression levels of miR-21-5p and PTEN was observed in GC samples (r=−0.4175, P=0.0039). (D) A statistically significant negative correlation between the expression levels of miR-21-5p and TIMP3 was observed in GC samples (r=−0.3263, P=0.004). GC, gastric cancer; PTEN, phosphatase and tensin homologue; TIMP3, tissue inhibitor of matrix metalloproteinases 3; miR, microRNA.