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Suppression of natural killer (NK) cell CD56 expression by Leishmania does not affect cytokine-induced interferon (IFN)-γ production. Human peripheral blood mononuclear cells were stimulated by Leishmania promastigotes (multiplicity of infection 10) in the absence or presence of interleukin (IL)-12 and IL-18 (10 ng/ml each) for 20 h. Intracellular IFN-γ in NKp46+CD3− NK cells was measured by flow cytometry. Results of one of two donors analyzed are shown.
