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. 2018 Feb 2;9:134. doi: 10.3389/fimmu.2018.00134

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Copyright © 2018 Silva and Belisle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The biosynthesis of resolvin D1 (RvD1). The resolvins from the E-series (resolvins E1–E3) are synthesized from eicosapentaenoic acid (EPA), while maresins (maresin-1 and maresin-2), protectins (protectin-1 and neuroprotectin-1), and resolvins of the series-D (resolvins D1–D6) are produced from docosahexaenoic acid (DHA). RvD1 is generated from the sequential oxygenation of DHA, a process catalyzed by 15-lipoxygenase (15-LO) and 5-lipoxygenase (5-LO). The initial conversion of DHA to 17S-HpDHA is catalyzed by 15-LO, followed a second lipoxygenation via 5-LO, which gives a peroxide intermediate that is transformed to 7S-,8S-epoxid-17S-hydroxy-DHA. Subsequently, the enzymatic hydrolysis of this compound generates the trihydroxylated product RvD1.