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. 2018 Jan 26;9:83. doi: 10.3389/fimmu.2018.00083

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Copyright © 2018 Xiong, Qiu, Li, Qiu, Guo, Liu, Wan, Li, Wu, Wang, Zhou, Dong, Du, Chen and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fortunellin ameliorated colitis symptoms. (A) Hematoxylin and eosin-staining analysis of rat colonic tissue. Effects of fortunellin on (B) body weight, (C) food intake, (D) macroscopically visible damage, and (E) colon weight-to-length ratio in rats with colitis. Data are expressed as the mean ± SD. **P < 0.01 compared with the sham group (n = 7); ^##P < 0.01 compared with the 2,4,6-trinitrobenzene sulfonic acid control group (n = 7). SASP, sulfasalazine; fortunellin (L), 20 mg/kg fortunellin; fortunellin (H), 80 mg/kg fortunellin.