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. 2018 Jan 26;9:83. doi: 10.3389/fimmu.2018.00083

Figure 3.

Figure 3

Fortunellin reversed intestinal barrier loss and excessive oxidative stress in colitis. Rats with colitis were gavaged with fortunellin (L, 20 mg/kg/day; H, 80 mg/kg/day) for 14 days, then, expressions of serum fluorescein isothiocyanate-4 kD dextran (FD-4) level (A) and colonic expressions of malonaldehyde (MDA) level (B), glutathione (GSH) levels (C), and superoxide dismutase (SOD) (D) levels from different groups were measured by ELISA. Caco-2 monolayers were incubated with 100 ng/mL lipopolysaccharides (LPS) in the presence or absence of fortunellin for 24 h, and then the reactive oxygen species (ROS) content was measured by flow cytometer (E). **P < 0.01 compared with the sham group (n = 7); ##P < 0.01 compared with 2,4,6-trinitrobenzene sulfonic acid (TNBS) control group or LPS control group (n = 7).