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. 2018 Jan 26;9:83. doi: 10.3389/fimmu.2018.00083

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Copyright © 2018 Xiong, Qiu, Li, Qiu, Guo, Liu, Wan, Li, Wu, Wang, Zhou, Dong, Du, Chen and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fortunellin reversed the abnormal expression of phosphatase and tensin homolog (PTEN) and microRNA-374a in colitis. Rats with colitis were gavaged with fortunellin (L, 20 mg/kg/day; H, 80 mg/kg/day) for 14 days, then colonic expression of PTEN were measured by immunohistochemistry (A) and western blotting (C) respectively. The expression of microRNA-374a (miR-374a) were measured by RT-qPCR (B). **P < 0.01 compared with the sham group (n = 7); ^##P < 0.01 compared with the 2,4,6-trinitrobenzene sulfonic acid (TNBS) control group (n = 7).