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. 2018 Jan 26;9:83. doi: 10.3389/fimmu.2018.00083

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Copyright © 2018 Xiong, Qiu, Li, Qiu, Guo, Liu, Wan, Li, Wu, Wang, Zhou, Dong, Du, Chen and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fortunellin attenuated cell apoptosis in colitis. Effects of fortunellin (L, 20 mg/kg/day; H, 80 mg/kg/day) on the enhanced epithelial cell apoptosis level in colitis by TUNEL assay. Colonic tissues were subjected to TUNEL and imaging by fluorescence microscopy (A). Effects of fortunellin on protein expression of apoptosis-related proteins (B) caspase-3, (C) Bax, (D) Bcl-2 and phosphorylation levels of (E) GSK-3β and (F) Akt induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) were measured. **P < 0.01 compared with TNBS control group (n = 7).