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. 2018 Jan 26;9:83. doi: 10.3389/fimmu.2018.00083

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Copyright © 2018 Xiong, Qiu, Li, Qiu, Guo, Liu, Wan, Li, Wu, Wang, Zhou, Dong, Du, Chen and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of microRNA-374a inhibited fortunellin-induced amelioration effects on colitis symptoms. miR-374a knockdown using miR-374a antagomir pre-injection inhibited the amelioration effects of fortunellin on (A) micromorphology tested by Hematoxylin and eosin-staining of rat colonic tissue, (B) macroscopically visible damage, (C) colon weight/length ratio, (D) myeloperoxidase (MPO) activity, and (E) intestinal permeability in colitis. Data are expressed as the mean ± SD; **P < 0.01 compared with as indicated (n = 10). Data in the sham group is set to 100%; other data are relative values. Fortunellin (L), 20 mg/kg fortunellin; fortunellin (H), 80 mg/kg fortunellin.