Figure 5.

Intra-family and inter-family networks between core OTUs were constructed for luminal samples (A,C) and mucosal samples (B,D), respectively. The color of each node indicates the taxonomic group of those core OTUs at the family level. Only significant correlations (two-sided pseudo p ≤ 0.05 based on bootstrapping of 100 repetitions) with an absolute correlation magnitude ≥ 0.6 were presented. Nodes represent OTUs involved in either significant co-abundance (red edges) or co-exclusion (blue edges) relationships. Density plots indicate the magnitudes of the significant inter-family and intra-family correlation (p ≤ 0.05 following bootstrapping) among core OTUs in the luminal microbiome (E) and the mucosa-attached microbiome (F).