Table 4.
Adjusted marginal structural models for hazard ratios of cause‐specific mortality
| Type of death | N=6712 coded deaths | aHR (95% CI) Tuberculosis | aHR (95% CI) Pneumocystis | aHR (95% CI) Non‐Hodgkin Lymphoma | aHR (95% CI) All ADEs |
|---|---|---|---|---|---|
| ADEs | 2661 | 2.65 (2.20 to 3.19) | 5.10 (4.36 to 5.97) | 29.49 (25.48 to 34.13) | 7.51 (6.64 to 8.49) |
| NADEs | 4051 | 1.68 (1.38 to 2.04) | 2.21 (1.78 to 2.73) | 2.95 (2.12 to 4.10) | 2.21 (2.00 to 2.43) |
| NADE malignancy | 956 | 1.84 (1.23 to 2.76) | 2.12 (1.30 to 3.47) | 5.63 (3.46 to 9.16) | 2.59 (2.13 to 3.14) |
| Accident, suicide, overdose | 673 | 1.39 (0.81 to 2.38) | 2.60 (1.54 to 4.38) | 2.37 (0.90 to 6.26) | 1.37 (1.05 to 1.79) |
| Cardiovascular | 649 | 1.88 (1.15 to 3.08) | 1.74 (0.96 to 3.15) | 0.95 (0.20 to 4.46) | 1.95 (1.54 to 2.48) |
| NADE infection | 598 | 1.63 (1.05 to 2.54) | 2.66 (1.74 to 4.06) | 1.57 (0.45 to 5.47) | 2.17 (1.68 to 2.81) |
| Hepatic | 529 | 1.36 (0.77 to 2.40) | 1.06 (0.52 to 2.19) | 2.48 (0.79 to 7.76) | 2.09 (1.61 to 2.72) |
| Respiratory | 121 | 0.85 (0.24 to 2.92) | 6.76 (3.03 to 15.09) | 1.78 (0.44 to 7.16) | 4.28 (2.67 to 6.88) |
| Renal | 68 | 3.13 (0.88 to 11.19) | 0.95 (0.22 to 4.05) | 9.31 (2.25 to 38.45) | 5.81 (2.69 to 12.56) |
| Central nervous | 57 | 0.74 (0.10 to 5.47) | 0.66 (0.09 to 5.04) | a | 2.53 (1.18 to 5.44) |
| Metabolic | 41 | 4.30 (1.35 to 13.69) | a | a | 1.53 (0.67 to 3.47) |
| NADE, other | 359 | 1.77 (0.86 to 3.66) | 3.20 (1.40 to 7.30) | 2.45 (0.96 to 6.25) | 2.98 (2.14 to 4.16) |
a
Denotes that no deaths occurred in these categories.
+Models were adjusted for baseline CD4+ count, baseline HIV‐1 RNA, sex, HIV transmission risk group, age, calendar year of ART initiation, baseline ART regimen (PI/NNRTI/other), ADE at or prior to the time of enrolment, and ART‐CC cohort.