Table 5.
Adjusted marginal structural models for hazard ratios of cause‐specific mortality (excluding all sites with >50% missing codes of death)
| Type of death | N=4,664 coded deaths | aHR (95% CI) tuberculosis | aHR (95% CI) pneumocystis | aHR (95% CI) non‐Hodgkin lymphoma | aHR (95% CI) All ADEs |
|---|---|---|---|---|---|
| ADEs | 1841 | 3.34 (2.64 to 4.23) | 7.48 (6.06 to 9.23) | 31.23 (26.83 to 36.36) | 9.24 (8.08 to 10.58) |
| All NADEs | 2823 | 1.82 (1.41 to 2.36) | 1.58 (1.14 to 2.18) | 2.48 (1.74 to 3.53) | 2.23 (1.97 to 2.53) |
| NADE malignancy | 674 | 1.86 (1.10 to 3.15) | 0.70 (0.22 to 2.18) | 3.68 (2.10 to 6.46) | 2.14 (1.65 to 2.77) |
| Accident, Suicide, Overdose | 491 | 0.87 (0.33 to 2.31) | 1.18 (0.50 to 2.81) | 2.57 (0.98 to 6.72) | 1.14 (0.78 to 1.67) |
| Cardiovascular | 413 | 2.90 (1.57 to 5.36) | 0.99 (0.41 to 2.40) | 1.02 (0.23 to 4.64) | 2.11 (1.50 to 2.96) |
| Hepatic | 384 | 1.06 (0.52 to 2.19) | 1.08 (0.45 to 2.63) | 1.70 (0.42 to 6.83) | 1.83 (1.31 to 2.57) |
| NADE infection | 352 | 2.03 (1.09 to 3.77) | 3.01 (1.69 to 5.37) | 1.70 (0.49 to 5.98) | 2.50 (1.76 to 3.54) |
| Respiratory | 98 | 1.70 (0.50 to 5.80) | 4.81 (2.02 to 11.43) | 2.02 (0.50 to 8.08) | 4.72 (2.86 to 7.80) |
| Renal | 52 | 5.03 (1.41 to 17.94) | 1.23 (0.16 to 9.28) | 10.00 (2.51 to 39.88) | 9.19 (4.03 to 20.97) |
| Central nervous | 47 | 1.11 (0.15 to 8.12) | 1.31 (0.17 to 10.20) | a | 2.52 (1.15 to 5.50) |
| Metabolic | 28 | 1.57 (0.20 to 12.36) | a | a | 1.47 (0.54 to 3.99) |
| NADE, other | 284 | 2.09 (0.93 to 4.71) | 3.11 (1.16 to 8.32) | 2.75 (1.07 to 7.07) | 3.16 (2.18 to 4.57) |
a
Denotes that no deaths occurred in these categories.
+Models were adjusted for baseline CD4+ count, baseline HIV‐1 RNA, sex, HIV transmission risk group, age, calendar year of ART initiation, baseline ART regimen (PI/NNRTI/other), ADE at or prior to the time of enrolment, and ART‐CC cohort.