Table 5.
Themes explored in the collected trial data
| BCPP | MaxART | PopART | SEARCH | ANRS TasP | |
|---|---|---|---|---|---|
| Implementation of the UTT care cascade | |||||
| HIV testing | x | x | x | x | |
| Linkage to care | x | x | x | x | |
| Retention in care | x | x | x | x | x |
| ART initiation and adherence | x | x | x | x | x |
| Other HIV prevention services (e.g. PrEP, MC) | x | x | xa | ||
| Community's health | |||||
| HIV disease progression (according to CD4 cell counts and/or HIV viral loads) | x | x | x | x | x |
| AIDS or TB or other opportunistic infections (total number of cases and incident cases) | x | x | x | x | x |
| Other health problems (e.g. diabetes, hypertension chronic kidney disease) (total number of cases and incident cases)b | x | xb | x | ||
| ART‐associated toxicity and adverse events | x | x | x | x | x |
| Mortality (overall, HIV‐related, child and/or maternal) | x | x | x | x | x |
| Mother‐to‐child HIV‐1 transmission | x | ||||
| Community‐level HIV RNA metrics (e.g. community viral load, proportion of individuals with undetectable viral loads) | x | x | x | x | x |
| HIV drug resistance (transmitted or acquired virus mutations) | x | x | x | x | x |
| HIV phylogenetics (e.g. direction of HIV‐transmission events) | x | x | x | x | |
| Economic and health system impact OF UTT | |||||
| Cost per patient per year | x | x | x | x | x |
| Cost‐effectiveness (e.g. modelled cost per infection averted) | x | x | x | x | x |
| Heath system measures (e.g. time spent from clinic check‐in to completion of clinic visit) | x | x | x | x | |
| Community's experiences | |||||
| Participant social and behavioural characteristics (e.g. sexual behaviour and prevention practices, quality of life, social networks, experience of HIV‐related stigma) | x | x | x | x | x |
| Participant perceptions and attitudes towards the trial interventions (e.g. universal ART, overall care delivery, access to medical services) | x | x | x | x | |
| Community awareness of the trial interventions | x | x | x | x | |
| Providers attitudes towards the trial interventions | x | x | x | x | x |
UTT, universal testing and treatment; PrEP, pre‐exposure prophylaxis, MC, medical male circumcision.
a
Theme explored during the phase 2 of the SEARCH trial.
b
In the SEARCH trial, other health problems are assessed in both HIV‐ and non‐HIV‐infected individuals. In the other trials, they are only assessed in HIV‐infected individuals.