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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Stat Med. 2017 Nov 29;37(8):1276–1289. doi: 10.1002/sim.7554

Table 2.

The percent (%) bias, average bootstrap standard error (ASE) for SIMEX, average model standard error (ASE) for naive, empirical standard error (ESE), mean squared error (MSE), and coverage probabilities (CP) are given for 2000 simulated data sets for the SIMEX and naive methods with exponential time and a mean zero normal distribution for the error term. Type 1 error is shown instead of % bias for β = 0.

β
συ2
n Method % Bias ASE ESE MSE CP
log(1.5) 0.25 300 SIMEX −3.234 0.077 0.076 0.077 0.942
Naive −15.05 0.062 0.064 0.089 0.810
1000 SIMEX −3.432 0.041 0.041 0.043 0.930
Naive −15.25 0.033 0.033 0.070 0.535
0.5 300 SIMEX −8.815 0.082 0.082 0.089 0.921
Naive −23.72 0.060 0.062 0.114 0.633
1000 SIMEX −9.232 0.044 0.044 0.058 0.852
Naive −25.05 0.033 0.032 0.107 0.128
1 300 SIMEX −18.46 0.087 0.086 0.114 0.852
Naive −36.08 0.060 0.063 0.159 0.33
1000 SIMEX −18.90 0.046 0.047 0.090 0.615
Naive −36.64 0.033 0.035 0.153 0.007
log(3) 0.25 300 SIMEX −2.100 0.101 0.099 0.101 0.945
Naive −13.51 0.075 0.079 0.168 0.466
1000 SIMEX −2.172 0.054 0.053 0.058 0.922
Naive −13.98 0.041 0.043 0.159 0.049
0.5 300 SIMEX −6.780 0.107 0.107 0.130 0.889
Naive −22.07 0.072 0.076 0.254 0.112
1000 SIMEX −7.037 0.058 0.058 0.097 0.72
Naive −22.94 0.039 0.043 0.256 0.000
1 300 SIMEX −16.03 0.111 0.112 0.209 0.62
Naive −34.03 0.069 0.074 0.381 0.002
1000 SIMEX −16.40 0.060 0.061 0.190 0.16
Naive −34.53 0.037 0.041 0.382 0.000
β
συ2
n Method Type 1 Error ASE ESE MSE

0 0.25 300 SIMEX 0.052 0.071 0.071 0.071
1000 SIMEX 0.043 0.038 0.038 0.038
0.5 300 SIMEX 0.053 0.076 0.076 0.076
1000 SIMEX 0.045 0.040 0.040 0.040
1 300 SIMEX 0.056 0.081 0.081 0.081
1000 SIMEX 0.047 0.043 0.043 0.043