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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Stat Med. 2017 Nov 29;37(8):1276–1289. doi: 10.1002/sim.7554

Table 3.

The percent (%) bias, average bootstrap standard error (ASE) for SIMEX, average model standard error (ASE) for naive, empirical standard error (ESE), mean squared error (MSE), and coverage probabilities (CP) are given for 2000 simulated data sets for the SIMEX and naive methods with exponential time and a shifted gamma distribution (mean 0) for the error term. Type 1 error is shown instead of % bias for β = 0.

β
συ2
n Method % Bias ASE ESE MSE CP
log(1.5) 0.25 300 SIMEX −7.270 0.077 0.076 0.082 0.929
Naive −17.65 0.061 0.064 0.096 0.766
1000 SIMEX −8.025 0.041 0.041 0.053 0.864
Naive −18.33 0.033 0.034 0.082 0.379
0.5 300 SIMEX −16.98 0.081 0.082 0.107 0.841
Naive −30.01 0.060 0.063 0.137 0.483
1000 SIMEX −17.87 0.043 0.043 0.084 0.594
Naive −29.74 0.033 0.035 0.126 0.055
1 300 SIMEX −27.54 0.084 0.083 0.139 0.706
Naive −41.07 0.060 0.062 0.178 0.207
1000 SIMEX −28.37 0.044 0.045 0.124 0.278
Naive −42.45 0.032 0.034 0.176 0.003
log(3) 0.25 300 SIMEX −5.578 0.105 0.106 0.122 0.898
Naive −15.94 0.074 0.084 0.194 0.360
1000 SIMEX −6.380 0.057 0.059 0.091 0.758
Naive −16.55 0.040 0.047 0.188 0.017
0.5 300 SIMEX −15.96 0.113 0.122 0.214 0.636
Naive −27.45 0.070 0.089 0.314 0.042
1000 SIMEX −17.19 0.062 0.066 0.200 0.146
Naive −28.71 0.038 0.049 0.319 0.000
1 300 SIMEX −29.28 0.117 0.124 0.345 0.232
Naive −41.6 0.066 0.095 0.467 0.000
1000 SIMEX −30.91 0.065 0.068 0.346 0.001
Naive −42.43 0.035 0.049 0.469 0.000
β
συ2
n Method Type 1 Error ASE ESE MSE

0 0.25 300 SIMEX 0.049 0.071 0.069 0.069
1000 SIMEX 0.057 0.037 0.037 0.037
0.5 300 SIMEX 0.052 0.074 0.074 0.074
1000 SIMEX 0.049 0.039 0.039 0.039
1 300 SIMEX 0.037 0.077 0.075 0.075
1000 SIMEX 0.056 0.040 0.041 0.041